Doxurbicin

Doxurbicin

Share
Doxurbicin
Mesothelioma Drugs: Doxurbicin
 
 
What is Doxurbicin?
 
 
Doxurbicin is sued in combination with other drugs to treat certain types of cancer (primarily bladder, lung, stomach and ovarian cancer). Doxurbicin is administered as a powder or solution and is mixed with liquid to be injected through an IV. Doxurbicin is administered once every 3 to 4 weeks and the length of treatment is dependent on the types of drugs you are currently receiving, your medical condition, how well you respond to said treatment and the severity of your cancer. 
 
 
In general, there are three traditional mesothelioma treatments: surgery to extract the cancerous cells from the body (only applied to patients lucky enough to detect the disease at an early stage), chemotherapy, which utilizes a variety of drugs to kill the cancer and radiation therapy, which administers high doses of x-rays to terminate the cancerous cells. Frequently, mesothelioma patients must undergo a combination of these treatment options to prolong life. 
 
 
Doxurbicin is currently not available for clinical use. The patent for the drug expired during the winter of 2009; however, Doxurbicin is protected against generic competitors until 2014 because the Food and Drug Administration deems the drug as an “orphan drug”—a designation that awards Doxurbicin an extended protection as a way of rewarding pharmaceutical companies for researching and producing drugs for rare diseases. Doxurbicin is classified as an orphan drug because it affects less than 200,000 people in the United States. 
 
Adverse Side Effects of Doxurbicin:
 
 
Adverse side effects of Doxurbicin include: vomiting, hair loss, nausea and life-threatening heart damage. Moreover, Doxurbicin can cause neutropenia, which is a decrease in white blood cells.More mild side effects of Doxurbicin include: discoloration of urine and fatigue. 
When cumulative dosage of Doxurbicin increases to 550 mg, the risks of developing heart problems dramatically increases. Doxurbicin cardiotoxicity is characterized by dose-dependent declines in mitochondirla oxidative phosphorylation. 
 
 
How does Doxurbicin Fight Mesothelioma?
 
 
Doxurbicin may prove effective in combatting mesothelioma cancer because the drug interacts with DNA by way of inhibition and intercalation. This impedes the progression of the enzyme topoisomerase II which relaxes supercoils in DNA strands for transcription. Doxurbicin brings stability to the topoisomerase II complex after it breaks down the DNA chain for replication, inhibiting the DNA double helix from resealing and thereby halting the process of replication. As a result, mesothelioma cancer cells are blocked from spreading and proliferating beyond the disease’s point of origin. Doxurbicin’s efficacy rates; however, are elastic to diagnosis. If mesothelioma is not caught in its early stages proliferation will already have occurred. 
 

Comments

comments

Share

Related Articles


Latest Posts

Filing a Mesothelioma Class Action Suit

Read Full Article

Doxurbicin

Read Full Article
    Will I Need Surgery?

Will I Need Surgery?

Read Full Article

Mesothelioma Drugs Options

Read Full Article

Mesothelioma Immunotherapy Drugs

Read Full Article

Gemcitabine

Read Full Article

Navelbine

Read Full Article

What is ALIMTA

Read Full Article

Onconase

Read Full Article

Paclitaxel

Read Full Article

Pemetrexed

Read Full Article

Carboplatin

Read Full Article

Medical Expenses Suit

Read Full Article

Mesothelioma Case Discovery

Read Full Article

Types of Mesothelioma Drugs

Read Full Article

PET

Read Full Article

Pericardial Mesothelioma

Read Full Article

MRI Scan

Read Full Article

Multimodality Therapy

Read Full Article

Mesothelioma Risk Factors

Read Full Article

Immunotherapy

Read Full Article

Pathologist

Read Full Article

Thoracoscopy

Read Full Article

Smoking and Mesothelioma

Read Full Article

CT Scan

Read Full Article

Chest X-Ray

Read Full Article

Lung Function Tests

Read Full Article

Biopsy

Read Full Article

Mesothelioma Exercises

Read Full Article

Breathe Training

Read Full Article

Gene Therapy

Read Full Article

Combination Therapy

Read Full Article

Clinical Trials

Read Full Article

Diagnosing Mesothelioma

Read Full Article

Acupuncture

Read Full Article

Mesothelioma Chemotherapy

Read Full Article

Mesothelioma Radiation Therapy

Read Full Article

11 Things You Must Know About Mesothelioma

Read Full Article

Protect Yourself and Learn Mesothelioma Law

Read Full Article

Important Mesothelioma Information You Must Know

Read Full Article

Ease Financial Burdens with Mesothelioma Compensation

Read Full Article

How to Handle Mesothelioma Claims

Read Full Article

Learn About Mesothelioma Cancer

Read Full Article

Know the Risk Factors and Symptoms of Mesothelioma

Read Full Article

8 Things You Must Know About Malignant Mesothelioma

Read Full Article

What is Mesothelioma

Read Full Article

Mesothelioma Settlements

Read Full Article

Benign Mesothelioma

Read Full Article

Mesothelioma Surgery

Read Full Article

Mesothelioma Treatment

Read Full Article

Categories

Read previous post:
Asbestos Laws in California

Close